Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma

BACKGROUND: Euchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in epigenetic silencing of gene expression. EHMT1/2 also have direct roles in DNA repair and are implicated in chemoresistance in several...

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Detalles Bibliográficos
Autores principales: Watson, Zachary L., Yamamoto, Tomomi M., McMellen, Alexandra, Kim, Hyunmin, Hughes, Connor J., Wheeler, Lindsay J., Post, Miriam D., Behbakht, Kian, Bitler, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882350/
https://www.ncbi.nlm.nih.gov/pubmed/31775874
http://dx.doi.org/10.1186/s13148-019-0758-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882350/
https://www.ncbi.nlm.nih.gov/pubmed/31775874
http://dx.doi.org/10.1186/s13148-019-0758-2

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