Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd. Screening Collection) in thermal shift assay against bovine carbonic anhydrase (bCA) led to further validation of this new class of inhibitors a...

Descripción completa

Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Kalinin, Stanislav, Zozulya, Sergey, Griniukova, Anastasia, Borysko, Petro, Angeli, Andrea, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882446/
https://www.ncbi.nlm.nih.gov/pubmed/31752557
http://dx.doi.org/10.1080/14756366.2019.1693556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882446/
https://www.ncbi.nlm.nih.gov/pubmed/31752557
http://dx.doi.org/10.1080/14756366.2019.1693556

Ejemplares similares