Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site

A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7 cell line. The most of compounds displayed potent antiproliferative...

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Detalles Bibliográficos
Autores principales: Wang, Guangcheng, Liu, Wenjing, Gong, Zipeng, Huang, Yong, Li, Yongjun, Peng, Zhiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882462/
https://www.ncbi.nlm.nih.gov/pubmed/31724435
http://dx.doi.org/10.1080/14756366.2019.1690479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882462/
https://www.ncbi.nlm.nih.gov/pubmed/31724435
http://dx.doi.org/10.1080/14756366.2019.1690479

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