Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. However, C10a has some pharmacological defects and cyto...

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Detalles Bibliográficos
Autores principales: Yang, Lingling, Chen, Feng, Gao, Cheng, Chen, Jiabao, Li, Junyan, Liu, Siyan, Zhang, Yuanyuan, Wang, Zhouyu, Qian, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882489/
https://www.ncbi.nlm.nih.gov/pubmed/31742469
http://dx.doi.org/10.1080/14756366.2019.1690481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882489/
https://www.ncbi.nlm.nih.gov/pubmed/31742469
http://dx.doi.org/10.1080/14756366.2019.1690481

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