Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy

Therapeutic application of unmodified camptothecin (CPT) is severely restricted by its extremely low water solubility and the instability of active lactone ring. In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-OA) was used to deliver the lactone-stabilized CPT...

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Detalles Bibliográficos
Autores principales: Li, Fu, Huang, Zhao, Chen, Huitong, Yan, Lu, Li, Jin, Su, Yue, Zhang, Qian, Huang, Zhengye, Zheng, Yaxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882494/
https://www.ncbi.nlm.nih.gov/pubmed/31735094
http://dx.doi.org/10.1080/10717544.2019.1678696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882494/
https://www.ncbi.nlm.nih.gov/pubmed/31735094
http://dx.doi.org/10.1080/10717544.2019.1678696

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