Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine

Human postmortem studies suggest a major role for abnormalities in GABAergic interneurons in the prefrontal cortex in schizophrenia. Cortical interneurons differentiated from induced pluripotent stem cells (iPSCs) of schizophrenia subjects showed significantly lower levels of glutamate decarboxylase...

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Detalles Bibliográficos
Autores principales: Kathuria, Annie, Lopez-Lengowski, Kara, Watmuff, Bradley, McPhie, Donna, Cohen, Bruce M., Karmacharya, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882825/
https://www.ncbi.nlm.nih.gov/pubmed/31780643
http://dx.doi.org/10.1038/s41398-019-0660-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882825/
https://www.ncbi.nlm.nih.gov/pubmed/31780643
http://dx.doi.org/10.1038/s41398-019-0660-x

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