Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components of bile

The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activity of ToxT. Crystal structures of inhibited ToxT bo...

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Detalles Bibliográficos
Autores principales: Cruite, Justin T., Kovacikova, Gabriela, Clark, Kenzie A., Woodbrey, Anne K., Skorupski, Karen, Kull, F. Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882843/
https://www.ncbi.nlm.nih.gov/pubmed/31815195
http://dx.doi.org/10.1038/s42003-019-0686-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882843/
https://www.ncbi.nlm.nih.gov/pubmed/31815195
http://dx.doi.org/10.1038/s42003-019-0686-x

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