Two-tiered enforcement of high-fidelity DNA ligation

DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. To protect the integrity of the genome, DNA ligase 1 (LIG1) discriminates against DNA junctions harboring mutagenic 3′-DNA mismatches or oxidative DNA damage, but how such high-fidelit...

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Detalles Bibliográficos
Autores principales: Tumbale, Percy P., Jurkiw, Thomas J., Schellenberg, Matthew J., Riccio, Amanda A., O’Brien, Patrick J, Williams, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882888/
https://www.ncbi.nlm.nih.gov/pubmed/31780661
http://dx.doi.org/10.1038/s41467-019-13478-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882888/
https://www.ncbi.nlm.nih.gov/pubmed/31780661
http://dx.doi.org/10.1038/s41467-019-13478-7

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