Natural Product Inspired Novel Indole based Chiral Scaffold Kills Human Malaria Parasites via Ionic Imbalance Mediated Cell Death

Natural products offer an abundant source of diverse novel scaffolds that inspires development of next generation anti-malarials. With this vision, a library of scaffolds inspired by natural biologically active alkaloids was synthesized from chiral bicyclic lactams with steps/scaffold ratio of 1.7:1...

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Detalles Bibliográficos
Autores principales: Dangi, Poonam, Jain, Ravi, Mamidala, Rajanikanth, Sharma, Vijeta, Agarwal, Shalini, Bathula, Chandramohan, Thirumalachary, M., Sen, Subhabrata, Singh, Shailja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882913/
https://www.ncbi.nlm.nih.gov/pubmed/31780808
http://dx.doi.org/10.1038/s41598-019-54339-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882913/
https://www.ncbi.nlm.nih.gov/pubmed/31780808
http://dx.doi.org/10.1038/s41598-019-54339-z

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