The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

The human ATP-binding cassette transporter ABCG2 is a key to anticancer resistance and physiological detoxification. However, the molecular mechanism of substrate transport remains enigmatic. A hydrophobic di-leucine motif in the ABCG2 core separates a large intracellular cavity from a smaller upper...

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Detalles Bibliográficos
Autores principales: Khunweeraphong, Narakorn, Szöllősi, Daniel, Stockner, Thomas, Kuchler, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883074/
https://www.ncbi.nlm.nih.gov/pubmed/31780715
http://dx.doi.org/10.1038/s41467-019-13302-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883074/
https://www.ncbi.nlm.nih.gov/pubmed/31780715
http://dx.doi.org/10.1038/s41467-019-13302-2

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