MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma

Radiation therapy (RT) is a cornerstone of treatment in the management of head and neck squamous cell carcinomas (HNSCC), yet treatment failure and disease recurrence are common. The p38/MK2 pathway is activated in response to cellular stressors, including radiation, and promotes tumor inflammation...

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Detalles Bibliográficos
Autores principales: Berggren, Kiersten L., Cruz, Sebastian Restrepo, Hixon, Michael D, Cowan, Andrew, Keysar, Stephen B., Craig, Stephanie, James, Jacqueline, Barry, Marc, Ozbun, Michelle A., Jimeno, Antonio, McCance, Dennis J., Beswick, Ellen J., Gan, Gregory N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883149/
https://www.ncbi.nlm.nih.gov/pubmed/31417185
http://dx.doi.org/10.1038/s41388-019-0945-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883149/
https://www.ncbi.nlm.nih.gov/pubmed/31417185
http://dx.doi.org/10.1038/s41388-019-0945-9

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