The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis

Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids(1,2). The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols(3,4). Ferroptosis has...

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Detalles Bibliográficos
Autores principales: Bersuker, Kirill, Hendricks, Joseph, Li, Zhipeng, Magtanong, Leslie, Ford, Breanna, Tang, Peter H., Roberts, Melissa A., Tong, Bingqi, Maimone, Thomas J., Zoncu, Roberto, Bassik, Michael C., Nomura, Daniel K., Dixon, Scott J., Olzmann, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883167/
https://www.ncbi.nlm.nih.gov/pubmed/31634900
http://dx.doi.org/10.1038/s41586-019-1705-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883167/
https://www.ncbi.nlm.nih.gov/pubmed/31634900
http://dx.doi.org/10.1038/s41586-019-1705-2

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