Pragmatic dose-escalation methods incorporating relative dose intensity assessment for molecularly targeted agents in phase I trials

The recommended phase 2 doses of molecularly targeted agents, determined by using an ordinal dose-finding method that only uses toxicity data at first cycle, may not be optimal. Some researchers have proposed the use of relative dose intensity that can account for late-onset, cumulative, and low-gra...

Descripción completa

Detalles Bibliográficos
Autores principales: Hirakawa, Akihiro, Tanaka, Yuichi, Kaneko, Shuhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883296/
https://www.ncbi.nlm.nih.gov/pubmed/31799475
http://dx.doi.org/10.1016/j.conctc.2019.100489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883296/
https://www.ncbi.nlm.nih.gov/pubmed/31799475
http://dx.doi.org/10.1016/j.conctc.2019.100489

Ejemplares similares