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Acute liver failure in a military recruit treated with valproic acid and harboring a previously unrecognized POLG-1 mutation
Patients with mutations in the POLG-1 gene often are afflicted with drug-resistant seizures at an early age and have an increased risk of valproic acid-induced acute liver failure. Severe valproate hepatotoxicity most commonly arises in children within the first 3 months of treatment with an overall...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883298/ https://www.ncbi.nlm.nih.gov/pubmed/31799506 http://dx.doi.org/10.1016/j.ebr.2019.100342 |