N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q(9/10) levels

The diabetic heart has been linked with reduced endogenous levels of coenzyme Q(9/10) (CoQ), an important antioxidant and component of the electron transport chain. Although CoQ has displayed cardioprotective potential in experimental models of diabetes, the impact of N-acetyl cysteine (NAC) on mito...

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Detalles Bibliográficos
Autores principales: Dludla, Phiwayinkosi V., Orlando, Patrick, Silvestri, Sonia, Mazibuko-Mbeje, Sithandiwe E., Johnson, Rabia, Marcheggiani, Fabio, Cirilli, Ilenia, Muller, Christo J.F., Louw, Johan, Obonye, Nnini, Nyawo, Thembeka, Nkambule, Bongani B., Tiano, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883304/
https://www.ncbi.nlm.nih.gov/pubmed/31799124
http://dx.doi.org/10.1016/j.toxrep.2019.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883304/
https://www.ncbi.nlm.nih.gov/pubmed/31799124
http://dx.doi.org/10.1016/j.toxrep.2019.11.004

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