WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells

WEE1 kinase is a key regulator of the G2/M transition. The WEE1 kinase inhibitor AZD1775 (WEE1i) induces origin firing in replicating cells. We show that WEE1i induces CDK1-dependent RIF1 phosphorylation and CDK2- and CDC7-dependent activation of the replicative helicase. WEE1 suppresses CDK1 and CD...

Descripción completa

Detalles Bibliográficos
Autores principales: Moiseeva, Tatiana N., Qian, Chenao, Sugitani, Norie, Osmanbeyoglu, Hatice U., Bakkenist, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883772/
https://www.ncbi.nlm.nih.gov/pubmed/31712441
http://dx.doi.org/10.1073/pnas.1915108116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883772/
https://www.ncbi.nlm.nih.gov/pubmed/31712441
http://dx.doi.org/10.1073/pnas.1915108116

Ejemplares similares