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WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells

WEE1 kinase is a key regulator of the G2/M transition. The WEE1 kinase inhibitor AZD1775 (WEE1i) induces origin firing in replicating cells. We show that WEE1i induces CDK1-dependent RIF1 phosphorylation and CDK2- and CDC7-dependent activation of the replicative helicase. WEE1 suppresses CDK1 and CD...

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Detalles Bibliográficos
Autores principales:	Moiseeva, Tatiana N., Qian, Chenao, Sugitani, Norie, Osmanbeyoglu, Hatice U., Bakkenist, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883772/ https://www.ncbi.nlm.nih.gov/pubmed/31712441 http://dx.doi.org/10.1073/pnas.1915108116

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