aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions

Metastasis is the main cause of cancer-related deaths. How a single oncogenic cell evolves within highly organized epithelium is still unknown. Here, we found that the overexpression of the protein kinase atypical protein kinase C ι (aPKCi), an oncogene, triggers basally oriented epithelial cell ext...

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Detalles Bibliográficos
Autores principales: Villeneuve, Clémentine, Lagoutte, Emilie, de Plater, Ludmilla, Mathieu, Samuel, Manneville, Jean-Baptiste, Maître, Jean-Léon, Chavrier, Philippe, Rossé, Carine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883778/
https://www.ncbi.nlm.nih.gov/pubmed/31699818
http://dx.doi.org/10.1073/pnas.1906779116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883778/
https://www.ncbi.nlm.nih.gov/pubmed/31699818
http://dx.doi.org/10.1073/pnas.1906779116

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