Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

Trisomy 21 (T21) causes Down syndrome (DS), a condition characterized by high prevalence of autoimmune disorders. However, the molecular and cellular mechanisms driving this phenotype remain unclear. Building upon our previous finding that T cells from people with DS show increased expression of int...

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Detalles Bibliográficos
Autores principales: Araya, Paula, Waugh, Katherine A., Sullivan, Kelly D., Núñez, Nicolás G., Roselli, Emiliano, Smith, Keith P., Granrath, Ross E., Rachubinski, Angela L., Enriquez Estrada, Belinda, Butcher, Eric T., Minter, Ross, Tuttle, Kathryn D., Bruno, Tullia C., Maccioni, Mariana, Espinosa, Joaquín M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883781/
https://www.ncbi.nlm.nih.gov/pubmed/31699819
http://dx.doi.org/10.1073/pnas.1908129116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883781/
https://www.ncbi.nlm.nih.gov/pubmed/31699819
http://dx.doi.org/10.1073/pnas.1908129116

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