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Neutrophils promote VLA-4–dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation

The success of B cell depletion therapies and identification of leptomeningeal ectopic lymphoid tissue (ELT) in patients with multiple sclerosis (MS) has renewed interest in the antibody-independent pathogenic functions of B cells during neuroinflammation. The timing and location of B cell antigen p...

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Detalles Bibliográficos
Autores principales: Parker Harp, Chelsea R., Archambault, Angela S., Cheung, Matthew, Williams, Jesse W., Czepielewski, Rafael S., Duncker, Patrick C., Kilgore, Aaron J., Miller, Aidan T., Segal, Benjamin M., Kim, Alfred H. J., Randolph, Gwendalyn J., Wu, Gregory F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883802/
https://www.ncbi.nlm.nih.gov/pubmed/31699814
http://dx.doi.org/10.1073/pnas.1909098116