Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB

PdxB (erythronate 4-phosphate dehydrogenase) is expected to be required for synthesis of the essential cofactor pyridoxal 5′-phosphate (PLP) in Escherichia coli. Surprisingly, incubation of the ∆pdxB strain in medium containing glucose as a sole carbon source for 10 d resulted in visible turbidity,...

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Detalles Bibliográficos
Autores principales: Kim, Juhan, Flood, Jake J., Kristofich, Michael R., Gidfar, Cyrus, Morgenthaler, Andrew B., Fuhrer, Tobias, Sauer, Uwe, Snyder, Daniel, Cooper, Vaughn S., Ebmeier, Christopher C., Old, William M., Copley, Shelley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883840/
https://www.ncbi.nlm.nih.gov/pubmed/31712440
http://dx.doi.org/10.1073/pnas.1915569116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883840/
https://www.ncbi.nlm.nih.gov/pubmed/31712440
http://dx.doi.org/10.1073/pnas.1915569116

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