Cargando…

Identification and targeting of CD22ΔE12 as a molecular RNAi target to overcome drug resistance in high-risk B-lineage leukemias and lymphomas

AIM: CD22ΔE12 as an oncogenic driver lesion in aggressive and drug-resistant B-precursor acute lymphoblastic leukemia (BPL) cells. The purpose of the present study was to identify the CD22ΔE12-specific signature transcriptome in human BPL cells and evaluate the clinical potential of a nanoscale form...

Descripción completa

Detalles Bibliográficos
Autores principales: Uckun, Fatih M., Qazi, Sanjive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883925/
https://www.ncbi.nlm.nih.gov/pubmed/31788667
http://dx.doi.org/10.20517/cdr.2017.03