Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration

Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive multiple sclerosis (MS), resulting in inappropriate intrusion...

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Detalles Bibliográficos
Autores principales: Joshi, Dinesh C., Zhang, Chuan-Li, Babujee, Lavanya, Vevea, Jason D., August, Benjamin K., Sheng, Zu-Hang, Chapman, Edwin R., Gomez, Timothy M., Chiu, Shing Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884150/
https://www.ncbi.nlm.nih.gov/pubmed/31618636
http://dx.doi.org/10.1016/j.celrep.2019.09.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884150/
https://www.ncbi.nlm.nih.gov/pubmed/31618636
http://dx.doi.org/10.1016/j.celrep.2019.09.012

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