HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1

TBX5 is a T-box family transcription factor that regulates heart and forelimb development in vertebrates and functional deficiencies in this protein result in Holt-Oram syndrome. Recently, we have shown that acetylation of TBX5 potentiates its activity and is important for heart and limb development...

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Detalles Bibliográficos
Autores principales: Ghosh, Tushar K., Aparicio-Sánchez, José J., Buxton, Sarah, Brook, J. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884511/
https://www.ncbi.nlm.nih.gov/pubmed/31784580
http://dx.doi.org/10.1038/s41598-019-54312-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884511/
https://www.ncbi.nlm.nih.gov/pubmed/31784580
http://dx.doi.org/10.1038/s41598-019-54312-w

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