Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET

Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messen...

Descripción completa

Detalles Bibliográficos
Autores principales: Huynh, Nhan, Ou, Qiuxiang, Cox, Pendleton, Lill, Roland, King-Jones, Kirst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884552/
https://www.ncbi.nlm.nih.gov/pubmed/31784520
http://dx.doi.org/10.1038/s41467-019-13237-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884552/
https://www.ncbi.nlm.nih.gov/pubmed/31784520
http://dx.doi.org/10.1038/s41467-019-13237-8

Ejemplares similares