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Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET

Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messen...

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Detalles Bibliográficos
Autores principales:	Huynh, Nhan, Ou, Qiuxiang, Cox, Pendleton, Lill, Roland, King-Jones, Kirst
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884552/ https://www.ncbi.nlm.nih.gov/pubmed/31784520 http://dx.doi.org/10.1038/s41467-019-13237-8

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