Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1)

Overexpression of hST3Gal1 leads to hypersialylation of cell-surface glycoconjugates, a cancer-associated condition that promotes cell growth, migration and invasion. Upregulation of this enzyme in ovarian cancer is linked to cancer progression and metastasis, contributing also to chemotherapy resis...

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Detalles Bibliográficos
Autores principales: Ortiz-Soto, Maria Elena, Reising, Sabine, Schlosser, Andreas, Seibel, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884586/
https://www.ncbi.nlm.nih.gov/pubmed/31784620
http://dx.doi.org/10.1038/s41598-019-54384-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884586/
https://www.ncbi.nlm.nih.gov/pubmed/31784620
http://dx.doi.org/10.1038/s41598-019-54384-8

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