A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against bioactive small molecules. We identify Milciclib that...

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Detalles Bibliográficos
Autores principales: Ghezzi, Chiara, Wong, Alicia, Chen, Bao Ying, Ribalet, Bernard, Damoiseaux, Robert, Clark, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884612/
https://www.ncbi.nlm.nih.gov/pubmed/31784510
http://dx.doi.org/10.1038/s41467-019-13334-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884612/
https://www.ncbi.nlm.nih.gov/pubmed/31784510
http://dx.doi.org/10.1038/s41467-019-13334-8

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