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A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against bioactive small molecules. We identify Milciclib that...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884612/ https://www.ncbi.nlm.nih.gov/pubmed/31784510 http://dx.doi.org/10.1038/s41467-019-13334-8 |