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PD1(Hi) CD8(+) T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

BACKGROUND: CD8(+) T cells differentiate into exhausted status within tumors, including hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor immunity. A detailed characterization of exhausted T cells and their prognostic value in HCC is lacking. METHODS: We colle...

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Detalles Bibliográficos
Autores principales: Ma, Jiaqiang, Zheng, Bohao, Goswami, Shyamal, Meng, Lu, Zhang, Dandan, Cao, Chunmei, Li, Teng, Zhu, Fangming, Ma, Lijie, Zhang, Zhao, Zhang, Shuhao, Duan, Meng, Chen, Qin, Gao, Qiang, Zhang, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884778/
https://www.ncbi.nlm.nih.gov/pubmed/31783783
http://dx.doi.org/10.1186/s40425-019-0814-7