Targeting glycosylation of PD-1 to enhance CAR-T cell cytotoxicity

Asparagine-linked (N-linked) glycosylation is ubiquitous and can stabilize immune inhibitory PD-1 protein. Reducing N-linked glycosylation of PD-1 may decrease PD-1 expression and relieve its inhibitory effects on CAR-T cells. Considering that the codon of Asparagine is aac or aat, we wondered if th...

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Detalles Bibliográficos
Autores principales: Shi, Xiaojuan, Zhang, Daiqun, Li, Feng, Zhang, Zhen, Wang, Shumin, Xuan, Yujing, Ping, Yu, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884797/
https://www.ncbi.nlm.nih.gov/pubmed/31783892
http://dx.doi.org/10.1186/s13045-019-0831-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884797/
https://www.ncbi.nlm.nih.gov/pubmed/31783892
http://dx.doi.org/10.1186/s13045-019-0831-5

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