Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells

A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL). However, the downregulation of antiapoptot...

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Detalles Bibliográficos
Autores principales: Ha, Eun Ji, Kim, Ki Yun, Kim, Chae Eun, Jun, Do Youn, Kim, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885204/
https://www.ncbi.nlm.nih.gov/pubmed/31827702
http://dx.doi.org/10.1155/2019/7989276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885204/
https://www.ncbi.nlm.nih.gov/pubmed/31827702
http://dx.doi.org/10.1155/2019/7989276

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