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Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells

A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL). However, the downregulation of antiapoptot...

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Detalles Bibliográficos
Autores principales:	Ha, Eun Ji, Kim, Ki Yun, Kim, Chae Eun, Jun, Do Youn, Kim, Young Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885204/ https://www.ncbi.nlm.nih.gov/pubmed/31827702 http://dx.doi.org/10.1155/2019/7989276

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