Cargando…

CD137 ligand feedback upregulates PD‐L1 expression on lung cancer via T cell production of IFN‐γ

BACKGROUND: The expression of PD‐L1 and its regulation in tumors remains unclear. The importance of IFN‐γ in upregulating the PD‐L1 expression in various tumors, and the effects of other essential cytokines in the tumor microenvironment (TME), need to be further elucidated. METHODS: Constitutive exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Helin, Yan, Zhuohong, Hao, Jianqing, Yang, Bin, Wang, Jinghui, Yi, Ling, Wang, Xiaojue, Li, Shuping, Zhang, Hongtao, Zhang, Shucai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons Australia, Ltd 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885434/ https://www.ncbi.nlm.nih.gov/pubmed/31625289 http://dx.doi.org/10.1111/1759-7714.13207

Ejemplares similares

CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer
por: Yi, Ling, et al.
Publicado: (2022)

Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
por: Yi, Ling, et al.
Publicado: (2014)

Association between response to anti-PD-1 treatment and blood soluble PD-L1 and IL-8 changes in patients with NSCLC
por: Yi, Ling, et al.
Publicado: (2023)

Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome
por: Li, Shuping, et al.
Publicado: (2022)

CD137-CD137 Ligand Interactions in Inflammation
por: Kwon, Byungsuk
Publicado: (2009)

PCSK9 regulates the efficacy of immune checkpoint therapy in lung cancer
por: Gao, Xiang, et al.
Publicado: (2023)

Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS
por: Yoyen-Ermis, Digdem, et al.
Publicado: (2019)

Enhanced Serum IgG Detection Potential Using 38KD-MPT32-MPT64, CFP10-Mtb81-EspC Fusion Protein and Lipoarabinomannan (LAM) for Human Tuberculosis
por: Yan, Zhuohong, et al.
Publicado: (2022)

Immunoassay with Novel Paired Antibodies for Detection of Lipoarabinomannan in the Pleural Fluid and Plasma of Patients with Tuberculous Pleurisy
por: Yan, Zhuohong, et al.
Publicado: (2023)

Isolation of circulating tumor cells and detection of EGFR mutations in patients with non-small-cell lung cancer
por: Zhang, Qi, et al.
Publicado: (2019)

IFN-γ surmounts PD-L1/PD1 inhibition to CAR-T cell therapy by upregulating ICAM-1 on tumor cells
por: Dong, E, et al.
Publicado: (2021)

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
por: Martin, Valentina, et al.
Publicado: (2019)

CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion
por: Rose, Marie-Clare St., et al.
Publicado: (2013)

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response
por: Liu, LanLan, et al.
Publicado: (2020)

Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
por: Kwon, Byungsuk
Publicado: (2015)

A Modified Method to Isolate Circulating Tumor Cells and Identify by a Panel of Gene Mutations in Lung Cancer
por: Wang, Helin, et al.
Publicado: (2021)

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
por: Luu, Khang, et al.
Publicado: (2021)

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity
por: Choi, Beom K., et al.
Publicado: (2020)

IFN-γ, should not be ignored in SLE
por: Liu, Wenping, et al.
Publicado: (2022)

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression
por: Wang, Huanhuan, et al.
Publicado: (2022)

IL-17A Synergizes with IFN-γ to Upregulate iNOS and NO Production and Inhibit Chlamydial Growth
por: Zhang, Yongci, et al.
Publicado: (2012)

IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer
por: Ding, Guoping, et al.
Publicado: (2019)

MicroRNA-155-IFN-γ Feedback Loop in CD4(+)T Cells of Erosive type Oral Lichen Planus
por: Hu, Jing-Yu, et al.
Publicado: (2015)

Upregulated Expression of Cytotoxicity-Related Genes in IFN-γ Knockout Mice with Schistosoma japonicum Infection
por: Du, Xiaotang, et al.
Publicado: (2011)

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
por: Qian, Jiawen, et al.
Publicado: (2018)

PD-1(+) IFN-γ(+) subset of CD8(+) T cell in circulation predicts response to anti–PD-1 therapy in NSCLC
por: Chen, Wenxiu, et al.
Publicado: (2023)

Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens
por: Draghi, Arianna, et al.
Publicado: (2021)

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
por: Wong, Hiu Yi, et al.
Publicado: (2020)

Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade
por: Vackova, Julie, et al.
Publicado: (2020)

IFN-γ Induces PD-L1 Expression in Primed Human Basophils
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2022)

Species Difference of CD137 Ligand Signaling in Human and Murine Monocytes
por: Tang, Qianqiao, et al.
Publicado: (2011)

Regulation of Inflammation by Bidirectional Signaling through CD137 and Its Ligand
por: Kwon, Byungsuk
Publicado: (2012)

IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
por: Zheng, Hui, et al.
Publicado: (2023)

Inducible IFN-γ Expression for MHC-I Upregulation in Devil Facial Tumor Cells
por: Ong, Chrissie E. B., et al.
Publicado: (2019)

T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production
por: van Asten, Saskia D., et al.
Publicado: (2021)

PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment
por: Flies, Andrew S., et al.
Publicado: (2016)

Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity
por: Krisnawati, Dyah Ika, et al.
Publicado: (2019)

Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway
por: Xue, Weili, et al.
Publicado: (2019)

Campylobacter concisus upregulates PD-L1 mRNA expression in IFN-γ sensitized intestinal epithelial cells and induces cell death in esophageal epithelial cells
por: Lee, Seul A, et al.
Publicado: (2021)

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination
por: Zhang, Ying, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dn7tdf3cmop7drafnv2mt4v1n3