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Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina

Progressive degeneration of retinal ganglion cells (RGCs) will cause a blinding disease. Most of the study is focusing on the RGCs itself. In this study, we demonstrate a decline of the presynaptic rod bipolar cells (RBCs) response precedes RGCs loss and a decrease of protein kinase Cα (PKCα) protei...

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Detalles Bibliográficos
Autores principales: Shen, Yumeng, Luo, Xue, Liu, Shiliang, Shen, Ying, Nawy, Scott, Shen, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885518/
https://www.ncbi.nlm.nih.gov/pubmed/31787761
http://dx.doi.org/10.1038/s41419-019-2140-x