Knockout Of BIRC5 Gene By CRISPR/Cas9 Induces Apoptosis And Inhibits Cell Proliferation In Leukemic Cell Lines, HL60 And KG1

INTRODUCTION: Human Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) which encodes survivin exhibits multiple biological activities, such as cell proliferation and apoptosis. Survivin is overexpressed in numerous malignant diseases including acute myeloid leukemia (AML). Recent studies...

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Detalles Bibliográficos
Autores principales: Narimani, Manizheh, Sharifi, Mohammadreza, Jalili, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885567/
https://www.ncbi.nlm.nih.gov/pubmed/31819702
http://dx.doi.org/10.2147/BLCTT.S230383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885567/
https://www.ncbi.nlm.nih.gov/pubmed/31819702
http://dx.doi.org/10.2147/BLCTT.S230383

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