Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism

Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) and a central component of the NO-cGMP pathway, critical to cardiovascular function. NO binding to the N-terminal sensor domain in sGC enhances the cyclase activity of the C-terminal catalytic domain. Our understanding of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Childers, Kenneth C., Yao, Xin-Qiu, Giannakoulias, Sam, Amason, Joshua, Hamelberg, Donald, Garcin, Elsa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Editors' Picks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885636/
https://www.ncbi.nlm.nih.gov/pubmed/31645439
http://dx.doi.org/10.1074/jbc.RA119.011010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885636/
https://www.ncbi.nlm.nih.gov/pubmed/31645439
http://dx.doi.org/10.1074/jbc.RA119.011010

Ejemplares similares