Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins

Detecting the targets of drugs and other molecules in intact cellular contexts is a major objective in drug discovery and in biology more broadly. Thermal proteome profiling (TPP) pursues this aim at proteome-wide scale by inferring target engagement from its effects on temperature-dependent protein...

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Detalles Bibliográficos
Autores principales: Childs, Dorothee, Bach, Karsten, Franken, Holger, Anders, Simon, Kurzawa, Nils, Bantscheff, Marcus, Savitski, Mikhail M., Huber, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2019
Materias:
Technological Innovation and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885700/
https://www.ncbi.nlm.nih.gov/pubmed/31582558
http://dx.doi.org/10.1074/mcp.TIR119.001481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885700/
https://www.ncbi.nlm.nih.gov/pubmed/31582558
http://dx.doi.org/10.1074/mcp.TIR119.001481

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