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Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins
Detecting the targets of drugs and other molecules in intact cellular contexts is a major objective in drug discovery and in biology more broadly. Thermal proteome profiling (TPP) pursues this aim at proteome-wide scale by inferring target engagement from its effects on temperature-dependent protein...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885700/ https://www.ncbi.nlm.nih.gov/pubmed/31582558 http://dx.doi.org/10.1074/mcp.TIR119.001481 |