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Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure. PARP-1 enzymatic activity has been shown to be necessary for the expression of several genes required for memory formation and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885846/ https://www.ncbi.nlm.nih.gov/pubmed/31827497 http://dx.doi.org/10.1155/2019/4383258 |