Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure. PARP-1 enzymatic activity has been shown to be necessary for the expression of several genes required for memory formation and...

Descripción completa

Detalles Bibliográficos
Autores principales: Regier, Matthew, Liang, Jiancong, Choi, Alexander, Verma, Kavita, Libien, Jenny, Hernández, A. Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885846/
https://www.ncbi.nlm.nih.gov/pubmed/31827497
http://dx.doi.org/10.1155/2019/4383258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885846/
https://www.ncbi.nlm.nih.gov/pubmed/31827497
http://dx.doi.org/10.1155/2019/4383258

Ejemplares similares