Cargando…
Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure. PARP-1 enzymatic activity has been shown to be necessary for the expression of several genes required for memory formation and...
Autores principales: | Regier, Matthew, Liang, Jiancong, Choi, Alexander, Verma, Kavita, Libien, Jenny, Hernández, A. Iván |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885846/ https://www.ncbi.nlm.nih.gov/pubmed/31827497 http://dx.doi.org/10.1155/2019/4383258 |
Ejemplares similares
-
Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition
por: Zeng, Jianying, et al.
Publicado: (2016) -
Nucleolar Integrity Is Required for the Maintenance of Long-Term Synaptic Plasticity
por: Allen, Kim D., et al.
Publicado: (2014) -
The Early Indicators of Functional Decrease in Mild Cognitive Impairment
por: Kubicki, Alexandre, et al.
Publicado: (2016) -
Early nucleolar disorganization in Dictyostelium cell death
por: Luciani, M F, et al.
Publicado: (2017) -
The multifunctional protein YB-1 potentiates PARP1 activity and decreases the efficiency of PARP1 inhibitors
por: Alemasova, Elizaveta E., et al.
Publicado: (2018)