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mTORC2 affects the maintenance of the muscle stem cell pool

BACKGROUND: The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, PKC, and SGK. Inactivation of mTORC2 signaling in adult skeletal muscle affects...

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Detalles Bibliográficos
Autores principales: Rion, Nathalie, Castets, Perrine, Lin, Shuo, Enderle, Leonie, Reinhard, Judith R., Rüegg, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886171/
https://www.ncbi.nlm.nih.gov/pubmed/31791403
http://dx.doi.org/10.1186/s13395-019-0217-y