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Joint between-sample normalization and differential expression detection through ℓ(0)-regularized regression
BACKGROUND: A fundamental problem in RNA-seq data analysis is to identify genes or exons that are differentially expressed with varying experimental conditions based on the read counts. The relativeness of RNA-seq measurements makes the between-sample normalization of read counts an essential step i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886201/ https://www.ncbi.nlm.nih.gov/pubmed/31787074 http://dx.doi.org/10.1186/s12859-019-3070-4 |