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Stochastic transcription in the p53‐mediated response to DNA damage is modulated by burst frequency

Discontinuous transcription has been described for different mammalian cell lines and numerous promoters. However, our knowledge of how the activity of individual promoters is adjusted by dynamic signaling inputs from transcription factors is limited. To address this question, we characterized the a...

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Detalles Bibliográficos
Autores principales: Friedrich, Dhana, Friedel, Laura, Finzel, Ana, Herrmann, Andreas, Preibisch, Stephan, Loewer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886302/
https://www.ncbi.nlm.nih.gov/pubmed/31885199
http://dx.doi.org/10.15252/msb.20199068