Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia

Olaptesed pegol (NOX-A12) is a pegylated structured L-oligoribonucleotide that binds and neutralizes CXCL12, a chemokine tightly regulating the life cycle of chronic lymphocytic leukemia cells. The resulting inhibition of CXCR4 and CXCR7 signaling reduces the protective activity of the bone marrow a...

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Detalles Bibliográficos
Autores principales: Steurer, Michael, Montillo, Marco, Scarfò, Lydia, Mauro, Francesca R., Andel, Johannes, Wildner, Sophie, Trentin, Livio, Janssens, Ann, Burgstaller, Sonja, Frömming, Anna, Dümmler, Thomas, Riecke, Kai, Baumann, Matthias, Beyer, Diana, Vauléon, Stéphanie, Ghia, Paolo, Foà, Robin, Caligaris-Cappio, Federico, Gobbi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886437/
https://www.ncbi.nlm.nih.gov/pubmed/31097627
http://dx.doi.org/10.3324/haematol.2018.205930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886437/
https://www.ncbi.nlm.nih.gov/pubmed/31097627
http://dx.doi.org/10.3324/haematol.2018.205930

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