Deep profiling and custom databases improve detection of proteoforms generated by alternative splicing

Alternative pre-mRNA splicing has long been proposed to contribute greatly to proteome complexity. However, the extent to which mature mRNA isoforms are successfully translated into protein remains controversial. Here, we used high-throughput RNA sequencing and mass spectrometry (MS)–based proteomic...

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Detalles Bibliográficos
Autores principales: Agosto, Laura M., Gazzara, Matthew R., Radens, Caleb M., Sidoli, Simone, Baeza, Josue, Garcia, Benjamin A., Lynch, Kristen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886501/
https://www.ncbi.nlm.nih.gov/pubmed/31727681
http://dx.doi.org/10.1101/gr.248435.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886501/
https://www.ncbi.nlm.nih.gov/pubmed/31727681
http://dx.doi.org/10.1101/gr.248435.119

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