Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice

Concordance for type 1 diabetes (T1D) is far from 100% in monozygotic twins and in inbred nonobese diabetic (NOD) mice, despite genetic identity and shared environment during incidence peak years. This points to stochastic determinants, such as postzygotic mutations (PZMs) in the expanding antigen-s...

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Detalles Bibliográficos
Autores principales: Alriyami, Maha, Marchand, Luc, Li, Quan, Du, Xiaoyu, Olivier, Martin, Polychronakos, Constantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886509/
https://www.ncbi.nlm.nih.gov/pubmed/31694869
http://dx.doi.org/10.1101/gr.247882.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886509/
https://www.ncbi.nlm.nih.gov/pubmed/31694869
http://dx.doi.org/10.1101/gr.247882.118

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