Synchronized replication of genes encoding the same protein complex in fast-proliferating cells

DNA replication perturbs the dosage balance among genes; at mid-S phase, early-replicating genes have doubled their copies while late-replicating ones have not. Dosage imbalance among genes, especially within members of a protein complex, is toxic to cells. However, the molecular mechanisms that cel...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Li, Ke, Chu, Xiao, Carey, Lucas B., Qian, Wenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886510/
https://www.ncbi.nlm.nih.gov/pubmed/31662304
http://dx.doi.org/10.1101/gr.254342.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886510/
https://www.ncbi.nlm.nih.gov/pubmed/31662304
http://dx.doi.org/10.1101/gr.254342.119

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