Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

Unregulated protein-tyrosine kinase signaling is a common feature of AML, often involving mutations in Flt3 and overexpression of myeloid Src-family kinases (Hck, Fgr, Lyn). Here we show that high-level expression of these Src kinases predicts poor survival in a large cohort of AML patients. To test...

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Detalles Bibliográficos
Autores principales: Patel, Ravi K., Weir, Mark C., Shen, Kexin, Snyder, Daniel, Cooper, Vaughn S., Smithgall, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886798/
https://www.ncbi.nlm.nih.gov/pubmed/31790499
http://dx.doi.org/10.1371/journal.pone.0225887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886798/
https://www.ncbi.nlm.nih.gov/pubmed/31790499
http://dx.doi.org/10.1371/journal.pone.0225887

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